1.新型脂环的结构设计👨🏻‍🚒👘、合成方法开发与生物应用研究

2.新型脂质体的合成方法开发与应用

1.Y. Yang†, J. Tsien†, R. Dykstra, S. Chen, J. B. Wang, R. R. Merchant, J. M. E. Hughes, B. K. Peters, O. Gutierrez*, T. Qin*. Exploring uncharted chemical space: Programmable late-stage functionalization of bridge-substituted BCP bis-boronates. Nat. Chem. 2022, accepted.

2.Y. Yang†, J. Tsien†, J. M. E. Hughes, B. K. Peters, R. R. Merchant, T. Qin*. An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates. Nat. Chem. 2021, 13, 950–955.

3.Y. Yang†, J. Tsien†, A. David, J. M. E. Hughes, R. R. Merchant*, T. Qin*. Practical and modular construction of C(sp3)-rich alkyl boron compounds. J. Am. Chem. Soc. 2021, 143, 471–480.

4.Y. Yang, L. Eberle, F. F. Mulks, J. F. Wunsch, M. Zimmer, F. Rominger, M. Rudolph, A. S. K. Hashmi*. Trans influence of ligands on the oxidation of gold(I) complexes. J. Am. Chem. Soc. 2019, 141, 17414–17420.

5.Y. Yang, P. Antoni, M. Zimmer, K. Sekine, F. Mulks, L. Hu, L. Zhang, M. Rudolph, F. Rominger, A. S. K. Hashmi*. Dual gold/silver catalysis involving alkynylgold(III) intermediates formed by oxidative addition and silver-catalyzed C–H activation for the direct alkynylation of cyclopropenes. Angew. Chem. Int. Ed. 2019, 58, 5129–5133. (very important paper)